The AAAI 2024 outstanding paper awards were announced at the conference on Thursday 22 February. These awards honour papers that “exemplify the highest standards in technical contribution and exposition”. Papers are recommended for consideration during the review process by members of the Program Committee. This year, three papers have been selected as outstanding papers.
Reliable Conflictive Multi-view Learning
Cai Xu, Jiajun Si, Ziyu Guan, Wei Zhao, Yue Wu, Xiyue Gao
Abstract: Multi-view learning aims to combine multiple features to achieve more comprehensive descriptions of data. Most previous works assume that multiple views are strictly aligned. However, real-world multi-view data may contain low-quality conflictive instances, which show conflictive information in different views. Previous methods for this problem mainly focus on eliminating the conflictive data instances by removing them or replacing conflictive views. Nevertheless, real-world applications usually require making decisions for conflictive instances rather than only eliminating them. To solve this, we point out a new Reliable Conflictive Multi-view Learning (RCML) problem, which requires the model to provide decision results and attached reliabilities for conflictive multi-view data. We develop an Evidential Conflictive Multi-view Learning (ECML) method for this problem. ECML first learns view-specific evidence, which could be termed as the amount of support to each category collected from data. Then, we can construct view-specific opinions consisting of decision results and reliability. In the multi-view fusion stage, we propose a conflictive opinion aggregation strategy and theoretically prove this strategy can exactly model the relation of multi-view common and view-specific reliabilities. Experiments performed on 6 datasets verify the effectiveness of ECML. The code is released at https://github.com/jiajunsi/RCML.
GxVAEs: Two Joint VAEs Generate Hit Molecules from Gene Expression Profiles
Chen Li and Yoshihiro Yamanishi
Abstract: The de novo generation of hit-like molecules that show bioactivity and drug-likeness is an important task in computer-aided drug discovery. Although artificial intelligence can generate molecules with desired chemical properties, most previous studies have ignored the influence of disease-related cellular environments. This study proposes a novel deep generative model called GxVAEs to generate hit-like molecules from gene expression profiles by leveraging two joint variational autoencoders (VAEs). The first VAE, ProfileVAE, extracts latent features from gene expression profiles. The extracted features serve as the conditions that guide the second VAE, which is called MolVAE, in generating hit-like molecules. GxVAEs bridge the gap between molecular generation and the cellular environment in a biological system, and produce molecules that are biologically meaningful in the context of specific diseases. Experiments and case studies on the generation of therapeutic molecules show that GxVAEs outperforms current state-of-the-art baselines and yield hit-like molecules with potential bioactivity and drug-like properties. We were able to successfully generate the potential molecular structures with therapeutic effects for various diseases from patients’ disease profiles.
Proportional Aggregation of Preferences for Sequential Decision Making
Nikhil Chandak, Shashwat Goel, Dominik Peters
Abstract: We study the problem of fair sequential decision making given voter preferences. In each round, a decision rule must choose a decision from a set of alternatives where each voter reports which of these alternatives they approve. Instead of going with the most popular choice in each round, we aim for proportional representation, using axioms inspired by the multi-winner voting literature. The axioms require that every group of α% of the voters, if it agrees in every round (i.e., approves a common alternative), then those voters must approve at least α% of the decisions. A stronger version of the axioms requires that every group of α% of the voters that agrees in a β fraction of rounds must approve β⋅α% of the decisions. We show that three attractive voting rules satisfy axioms of this style. One of them (Sequential Phragmén) makes its decisions online, and the other two satisfy strengthened versions of the axioms but make decisions semi-online (Method of Equal Shares) or fully offline (Proportional Approval Voting). We present empirical results for these rules based on synthetic data and U.S. political elections. We also run experiments using the moral machine dataset about ethical dilemmas. We train preference models on user responses from different countries and let the models cast votes. We find that aggregating these votes using our rules leads to a more equal utility distribution across demographics than making decisions using a single global preference model.
Read the full paper on arXiv.